Depression is often spoken about as if it were a single condition. In reality, it is a broad term that covers several distinct experiences, each with its own pattern of symptoms, triggers, and treatment needs. Understanding which type you may be living with can be the first step towards finding support that actually fits your circumstances.
This guide breaks down the main types of depression, explains how they differ, and looks at the treatment options available, including newer approaches such as ketamine treatment for those who have not responded to more conventional care.
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ToggleHow Many Types of Depression Are There?
There is no single agreed-upon number of depression types, as depression exists on a spectrum and clinicians may classify conditions in slightly different ways. However, most mental health frameworks recognise several key forms, including major depressive disorder, persistent depressive disorder, bipolar-related depression, seasonal affective disorder, postnatal or perinatal depression, premenstrual dysphoric disorder and situational depression.
Levels of Depression: Mild, Moderate and Severe
Before exploring the different types of depression, it is helpful to understand that depression can also be described by severity. These are often referred to as levels of depression.
Mild Depression
Mild depression may involve low mood, reduced motivation and some difficulty managing daily tasks. However, a person can usually continue with everyday responsibilities, even if it takes more effort than usual.
Moderate Depression
Moderate depression tends to cause more noticeable symptoms that begin to affect work, relationships, routines and self-care.
Severe Depression
Severe depression can significantly disrupt daily life. It may involve intense hopelessness, difficulty completing routine activities and, in some cases, thoughts of self-harm or suicide.
These levels are not separate diagnoses. Instead, they describe the intensity of symptoms within the type of depression a person is experiencing. Severity can also change over time, meaning someone may move between mild, moderate and severe depression at different points in their life.

There are a few main types of depression including clinical depression, persistent depressive disorder and bipolar disorder.
What are the Main Types of Depression?
Major Depressive Disorder or Clinical Depression
Major depressive disorder, often referred to as clinical depression, is one of the most recognised forms of depression. It typically involves a persistent low mood or loss of interest in usual activities for at least two weeks, along with symptoms such as fatigue, changes in sleep or appetite, difficulty concentrating, and feelings of worthlessness or guilt.
Episodes may happen once or recur throughout a person’s life. As major depressive disorder is well recognised and widely studied, there are several evidence-based treatment options available, including psychological therapies, medication and, in some cases, more specialised approaches.
Persistent Depressive Disorder or Dysthymia
Persistent depressive disorder is a longer-lasting form of depression that continues for two years or more. Symptoms may be less intense than those seen in a major depressive episode, but their ongoing nature can make them deeply exhausting and difficult to live with.
As it can develop gradually and become part of a person’s everyday experience, some people may assume they are simply “like this” rather than living with a treatable condition. Recognising persistent depressive disorder as a form of depression can be an important step towards getting support.
Bipolar Disorder and Depressive Episodes
Bipolar disorder involves episodes of depression as well as periods of elevated or unusually energised mood, known as mania or hypomania. The depressive episodes can look similar to major depression, with low mood, loss of interest, fatigue and changes in sleep or appetite.
Treatment, however, is different because bipolar disorder is a broader mood disorder. Some antidepressant medications, when used without appropriate mood-stabilising treatment, may increase the risk of triggering mania or hypomania.
Seasonal Affective Disorder or SAD
Seasonal affective disorder is a type of depression linked to seasonal changes. It most commonly appears during autumn and winter, when daylight hours are shorter, and may improve as spring or summer returns.
Symptoms can include low energy, oversleeping, increased appetite, carbohydrate cravings and social withdrawal. Treatment may involve light therapy, psychological therapy, medication or lifestyle strategies, depending on the person’s symptoms and circumstances.
Postnatal and Perinatal Depression
Perinatal depression occurs during pregnancy or in the year after childbirth. Postnatal depression refers specifically to depression that develops after the baby is born. Unlike the short-lived “baby blues”, which often ease within a couple of weeks, perinatal or postnatal depression is more persistent and can significantly affect daily life.
Symptoms may include ongoing sadness, anxiety, exhaustion, irritability, feelings of guilt, and difficulty bonding with the baby. It can affect mothers, fathers and partners, and deserves prompt, compassionate support.
Premenstrual Dysphoric Disorder or PMDD
Premenstrual dysphoric disorder is a severe form of premenstrual mood disturbance. It can cause significant depressive symptoms, irritability, anxiety and emotional sensitivity in the days leading up to menstruation.
Unlike typical premenstrual symptoms, PMDD can seriously disrupt work, relationships and daily life. As symptoms follow a cyclical pattern, tracking mood changes across the menstrual cycle can help with diagnosis and treatment planning.
Situational Depression or Adjustment Disorder
Situational depression can develop in response to a specific stressful or distressing event, such as bereavement, job loss, relationship breakdown, serious illness or major life change. Symptoms usually begin within weeks or months of the trigger and may include low mood, tearfulness, worry, withdrawal and difficulty coping.
For some people, symptoms ease as they adjust to the situation. For others, support or treatment may be needed to prevent symptoms from worsening or becoming long-lasting.
Treatment-Resistant Depression
Treatment-resistant depression is not usually considered a separate type of depression. Instead, it describes depression that has not improved after trying two or more antidepressant treatments at an appropriate dose and duration.
While it can feel frustrating and isolating, it does not mean a person is beyond help. In many cases, it means the treatment plan needs to be reviewed. Options may include reassessing the diagnosis, adjusting medication, combining treatments, exploring psychological therapies or considering specialist treatments where appropriate.

Depression can be treated in various ways, including talking therapies, antidepressant medication and lifestyle and self-management strategies.
How Are the Different Types of Depression Treated?
Depression treatment is not one-size-fits-all. The most appropriate approach depends on the type of depression, the severity of symptoms, a person’s mental health history and any other medical or psychological factors that may be involved.
Common treatment options may include:
- Talking therapies, such as cognitive behavioural therapy (CBT), interpersonal therapy or other forms of psychological support, can be helpful across many types of depression.
- Antidepressant medication, including SSRIs and SNRIs, may be recommended for moderate to severe depression or when symptoms are not improving with therapy alone.
- Lifestyle and self-management strategies, such as regular movement, sleep regulation, routine, stress management and social support. These are often used alongside other treatments rather than as a replacement for clinical care.
- Light therapy, which may be considered for seasonal affective disorder, particularly when symptoms are linked to reduced daylight during autumn and winter.
- Specialist treatment, especially for conditions such as bipolar disorder, where mood stabilisers or other psychiatric medications may play an important role.
For many people, a combination of treatments works best. If standard approaches have not provided enough relief, a psychiatrist may review the diagnosis, adjust the treatment plan or consider other options.
Ketamine as a Treatment for Depression
For people living with treatment-resistant depression, ketamine-based treatment may be considered in some circumstances. Unlike traditional antidepressants, which usually take several weeks to have an effect and primarily act on serotonin or noradrenaline pathways, ketamine works through a different brain pathway involving glutamate. For some people, this may be associated with a more rapid improvement in depressive symptoms.
Ketamine treatment is delivered in a carefully controlled clinical setting and should only take place after a thorough psychiatric assessment. It is not usually considered a first-line treatment and is generally reserved for people who have had limited improvement with more established treatment options.
Following psychiatric assessment, suitable patients receive ketamine within an individually tailored, consultant-led treatment plan, with ongoing clinical monitoring and review.
Start Your Assessment Process for Ketamine Treatment
If you are exploring ketamine treatment after a limited response to previous mental health care, you can contact Save Minds to begin the assessment process. The team can guide you through any referral requirements, arrange a psychiatric suitability assessment and help you understand whether this approach may be appropriate for your circumstances. Every enquiry is handled confidentially, and there is no obligation to proceed.
📞 +44 20 7722 0865
✉️ info@saveminds.co.uk
FAQs
What is the most common type of depression?
Major depressive disorder, also known as clinical depression, is one of the most commonly recognised forms of depression. It involves a persistent low mood or loss of interest that lasts at least 2 weeks, alongside symptoms that may affect sleep, appetite, energy, concentration, and self-worth.
Can you have more than one type of depression at once?
Yes. Some people experience overlapping forms of depression. For example, persistent depressive disorder can occur alongside episodes of major depression, sometimes referred to as “double depression”. A clinician can help identify which conditions may be present and recommend an appropriate treatment plan.
What is treatment-resistant depression?
Treatment-resistant depression refers to depression that has not improved after trying two or more appropriately prescribed antidepressant treatments at a suitable dose and duration. It does not mean recovery is impossible, but it may indicate that a different approach, such as specialist review, combination treatment or, where appropriate, ketamine-based treatment is needed.
Are there depression treatments that don’t involve medication?
Yes, talking therapies such as CBT, lifestyle changes, regular exercise, sleep support, social connection and light therapy may all play a role in managing depression. Depending on the type and severity of symptoms, these may be used alone or in combination with medication.
Can depression go away on its own?
Some milder or situational episodes may ease over time, particularly as circumstances change or support improves. However, many forms of depression benefit from treatment, and leaving symptoms unaddressed can allow them to persist or worsen.
How many types of depression are there?
There isn’t a fixed number, as depression is classified in different ways. However, most frameworks recognise several main forms, including major depressive disorder, persistent depressive disorder, bipolar-related depression, seasonal affective disorder, perinatal depression, premenstrual dysphoric disorder and situational depression.
Are all types of depression treated the same way?
No, treatment depends on the type of depression, its severity and the person’s individual circumstances. For example, bipolar depression requires a different approach from major depressive disorder, seasonal affective disorder may involve light therapy, and treatment-resistant depression may require specialist options such as ketamine-based treatment, where clinically appropriate.